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Actonel® (Risedronate Sodium) patient handout

• Actonel (Risedronate Sodium) is used to prevent and treat postmenopausal and corticosteroids induced osteoporosis.Also Actonel is used in the management of Paget's disease of bone in persons who : have a serum alkaline phosphatase level of at least twice normal, have symptoms or are at risk for complications.

• Actonel inhibits bone resorption by binding to bone hydroxyapatite, which inhibits osteoclast activity.
• Therapeutic effects of Actonel : reversal of the progression of osteoporosis with decreased fractures and other sequelae, reduced bone turnover and resorption, normalization of serum alkaline phosphatase with reduced complications of Paget's disease.

• Absorption Absorption describes the process that follows drug administration and its subsequent delivery to systemic circulation. : rapidly but poorly absorbed following oral administration (0.63% bioavailability).
• Distribution Drug's distribution in body tissues and fluids. : 60% of absorbed dose distributes to bone.
• Metabolism and excretion Important in determining dosage regimens and intervals for persons with hepatic or impaired renal function. : 40% of absorbed dose is excreted unchanged by kidneys; unabsorbed drug is excreted in feces.
• Half life The half-life of a drug is the amount of time it takes the drug level to decrease by 50% and roughly correlates with the duration of action. : initial - 1.5 hour; terminal - 220 hours (reflects dissociation from bone).

• Actonel (Risedronate Sodium) is contraindicated in : hypersensitivity, hypocalcemia, lactation, severe renal impairment.
• Use Actonel cautiously in : history of upper gastrointestinal disorders, other disturbances of bone or mineral metabolism, dietary deficiencies, pregnancy, children.

• Actonel side effects and adverse reactions can be : weakness, amblyopia, conjunctivitis, dry eyes, eye pain or inflammation, tinnitus, chest pain, edema, abdominal pain, diarrhea, belching, colitis, constipation, dysphagia, esophagitis, esophageal ulcer, gastric ulcer, leg cramps, myasthenia, flu like syndrome.

• It's very important to take Actonel (Risedronate Sodium) exactly as directed, first thing in the morning, 30 minutes prior to other medications, beverages or food.
• Actonel may reverse bone loss by stopping more bone loss and increasing bone strength.
• Don't chew or suck the Actonel tablet because doing so may irritate your mouth.
• Waiting longer than 30 minutes will improve absorption of Actonel.
• Actonel should be taken with 6 - 8 oz of plain water (mineral water, orange juice, coffee and other beverages decrease absorption).If a dose is missed, skip dose and resume the next morning; don't double doses or take later in the day.
• Don't discontinue Actonel therapy without consulting health care professional.
• Remain upright for 30 minutes following dose to facilitate passage to stomach and minimize risk of esophageal irritation.
• Eat a balanced diet and consult with your health care professional about the need for supplemental calcium and vitamin D.
• Participate in regular exercise and modify behaviors that increase the risk of osteoporosis (stop smoking, reduce alcohol consumption).
• Women : notify your health care professional if pregnancy is planned or suspected or if you're nursing.
• Store Actonel in a cool, dry place, at room temperature and away from children.
• If you miss a dose of the 35 mg tablet, take 1 tablet on the morning after you've remembered and return to take 1 tablet once a week, as originally scheduled on your chosen day.Don't take 2 Actonel tablets on the same day.