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Avandia® (Rosiglitazone Maleate) patient handout

• Avandia (Rosiglitazone Maleate) is used in the treatment of type 2 diabetes mellitus (with diet and exercise); Avandia may be used with metformin, sulfonylureas or insulin.

• Avandia improves sensitivity to insulin by acting as an agonist at receptor sites involved in insulin responsiveness and subsequent glucose production and utilization.Requires insulin for activity.
• Therapeutic effects of Avandia : decreased insulin resistance, resulting in glycemic control without hypoglycemia.

• Absorption Absorption describes the process that follows drug administration and its subsequent delivery to systemic circulation. : well absorbed (99%) following oral administration.
• Distribution Drug's distribution in body tissues and fluids. : unknown.
• Protein binding : 99,8% bound to plasma proteins.
• Metabolism and excretion Important in determining dosage regimens and intervals for persons with hepatic or impaired renal function. : entirely metabolized by the liver.
• Half life The half-life of a drug is the amount of time it takes the drug level to decrease by 50% and roughly correlates with the duration of action. : 3,2 to 3,6 hours (increased in liver disease).

• Avandia (Rosiglitazone Maleate) is strongly contraindicated in : hypersensitivity, diabetic ketoacidosis; clinical evidence of active liver disease or increased alanine transaminase (ALT), pregnancy or lactation, pedichildren under 18 years or type 1 diabetes.
• Use Avandia cautiously in : edema, concurrent use with insulin, hepatic impairment, women with childbearing potential.

• Avandia side effects and adverse reactions can be : headache, fatigue, edema, sinusitis, diarrhea, anemia, hyperglycemia, back pain, upper respiratory tract infection, accidental injury.

• Take Avandia (Rosiglitazone Maleate) as directed.If dose for 1 day is missed, don't double dose the next day.
• Avandia controls hyperglycemia but does not cure diabetes.Avandia therapy is long term.
• You should review signs of hypoglycemia and hyperglycemia.If hypoglycemia occurs take a glass of orange juice or 2-3 tablespoons of sugar, honey or corn syrup dissolved in water and notify health care professional.
• You must follow prescribed diet, medication and exercise regimen to prevent hypoglycemic or hyperglycemic episodes.
• You should know about proper testing of serum glucose and ketones.These tests should be closely monitored during periods of stress or illness and health care professional notified if significant changes occur.
• Notify health care professional immediately if signs of hepatic dysfunction (nausea, vomiting, abdominal pain) occur.
• Insulin is the preferred method of controlling blood glucose during pregnancy.Women : higher doses of oral contraceptives or a form or contraception other than oral contraceptives may be required and notify health care expert promptly if pregnancy is planned or suspected.
• Management of diabetes includes diet control, calorie restriction, weight loss and exercise and these measures improve effectiveness of Avandia therapy.
• Avoid other OTC (Over-The-Counter) medications or herbal preparations unless approved by prescriber.
• Carry emergency ID and glucagon emergency kit for emergencies.
• 2 weeks is needed to see a reduction in blood glucose and 2-3 months to see full effect.