Tell your doctor or pharmacist what medicines you are taking, including those bought
without a prescription and herbal medicines, before you start treatment with this
medicine. Likewise, always check with your doctor or pharmacist before taking any new
medicines during treatment with this one.
The following medicines may enhance the blood sugar lowering effect of Diamicron. This
may cause low blood sugar (
hypoglycaemia) and this
may happen unpredictably:
- the antifungal medicine miconazole (miconazole should not be taken with
Diamicron)
- other antidiabetic medicines
- ACE inhibitors, eg captopril, enalapril
- anticoagulants, eg warfarin
- large doses of aspirin (small pain-killing doses do not normally have this
effect)
- beta-blockers, eg propranolol (plus beta-blockers may mask the signs of low blood
sugar, such as increased heart rate and tremor)
- cimetidine
- fibrates, eg clofibrate
- disopyramide
- monoamine oxidase inhibitor (
MAOI)
antidepressants, eg phenelzine
- non-steroidal anti-inflammatory drugs (
NSAIDs), eg phenylbutazone, azapropazone
- sulphonamide antibiotics, eg co-trimoxazole
- tetracycline antibiotics, eg oxytetracycline, doxycycline.
The following medicines may increase blood sugar levels and therefore oppose the blood
sugar lowering effect of gliclazide:
- chlorpromazine
- corticosteroids, eg prednisolone
- danazol
- oral contraceptives
- thiazide diuretics, eg bendrofluazide.
Diamicron may increase the anti-blood-clotting effects of anticoagulant medicines such as
warfarin.