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Starlix® (Nateglinide) patient handout

• Starlix (Nateglinide) is used to improve glycemic control in persons with type 2 diabetes (with diet and exercise); Starlix may also be used with Glucophage (Metformin) or a thiazolidinedione (pioglitazone, rosiglitazole)

• Starlix stimulates the release of insulin from pancreatic beta cells by closing potassium channels, which results in the opening of calcium channels in betta cells.This is followed by release of insulin.Requires functioning pancreatic beta cells.
• Therpeutic effects of Starlix : lowering of blood glucose.

• Absorption Absorption describes the process that follows drug administration and its subsequent delivery to systemic circulation. : well absorbed (73%) following oral administration; absorption is rapid.
• Distribution Drug's distribution in body tissues and fluids. : unknown.
• Protein binding : 98%
• Metabolism and excretion Important in determining dosage regimens and intervals for persons with hepatic or impaired renal function. : mostly metabolized by the liver (cytochrome P2 C9 and P3 A4 [CYP2 C9 and CYP3 A4] enzyme systems); 16% excreted unchanged in urine.
• Half life The half-life of a drug is the amount of time it takes the drug level to decrease by 50% and roughly correlates with the duration of action. : 1,5 hour.

• Starlix (Nateglinide) is contraindicated in : hypersensitvity; pregnancy or lactation (insulin recommended to control diabetes during pregnancy); diabetic ketoacidosis; type 1 diabetes.
• Use Starlix cautiously in : elderly persons, malnourished persons, persons with pituitary or adrenal insufficiency, strenous physical exercise, insufficient caloric intake, autonomic neuropathy, moderate to severe liver impairment, fever, infection, trauma or surgery, children.

• Starlix side effects and adverse reactions can be : dizziness, diarrhea, hypoglycemia, back pain, arthropathy, upper respiratory tract infection, bronchitis, coughing, flulike symptoms, accidental trauma.

• Take Starlix (Nateglinide) at same time each day as prescribed.Take missed doses as soon as remembered unless almost time for next dose.Please don't take Starlix if you're unable to eat.
• Starlix controls hyperglycemia but doesn't cure diabetes.Starlix therapy is long term.
• If hypoglycemia occurs, take a glass of orange juice or 2-3 tablespoons of sugar, honey or corn syrup dissolved in water and notify health care professional.
• You must follow prescribed diet, medication and exercise regimen to prevent hypoglycemic or hyperglycemic episodes.
• You should learn about the proper testing of serum glucose and ketones.These tests should be closely monitored during periods of stress or illness and health care professional notified if significant changes occur.
• Starlix may occasionally cause dizziness.Avoid driving or other activities requiring alertness until response to medication is known.
• Avoid other medications, especially aspirin and alcohol, while on this therapy without consulting health care professional.
• Insulin is the recommended method of controlling blood glucose during pregnancy.Women : use a form of contraception other than oral contraceptives and notify health care professional promptly if pregnancy is planned or suspected.
• Inform health care expert of this medication regimen prior to treatment or surgery.
• Carry a form of sugar (sugar packets or sugar candy) and identification describing disease process and medication regimen at all times.
• You should follow-up all your exams for Starlix therapy.
• Skip the scheduled Starlix dose if you skip a meal to reduce risk of hypoglycemia.