Wellbutrin decreases neuronal reuptake of dopamine in the central nervous system; diminished neuronal uptake of serotonin and norepinephrine (less than tricylic antidepressants).
Wellbutrin (Bupropion HCL) is contraindicated in : persons hypersensitive to Wellbutrin, persons who have taken MAO inhibitors within previous 14 days, persons with seizure disorders or history of bulimia or anorexia nervosa because of a higher risk of seizures, persons abruptly stopping use of alcohol or sedatives (including benzodiazepines).
Use Wellbutrin cautiously in persons with : recent history of myocardial infarction, unstable heart disease, renal or hepatic impairment, a history of seizures, head trauma, or other predisposition to seizures; and persons being treated with drugs that lower seizure threshold.
Wellbutrin (immediate-release) : 100 mg twice daily initially; after 3 days you may increase to 100 mg 3 times daily; after at least 4 weeks of Wellbutrin therapy, you may increase dose up to 450 mg / day in divided doses (but don't exceed 150 mg / dose; wait at least 6 hours between doses at the 450 mg / day dose).
Wellbutrin SR (sustained-release) : 150 mg once daily in the morning; after 3 days you may increase dose to 150 mg twice daily with at least 8 hours between doses; after at least 4 weeks of Wellbutrin SR therapy, dose may be increased to maximum daily dose of 400 mg taken as 200 mg twice daily.
Wellbutrin XL (extended-release) : 150 mg once daily in the morning, you may increase after 4 days to 300 mg once daily; some persons may require up to 450 mg / day as a single daily dose.
Do not administer Wellbutrin concurrent with Zyban because Zyban contain the same ingredients as Wellbutrin, but is used for smoking cessation.
Administer Wellbutrin doses in equally spaced time increments during day to minimize the risk of seizures.Riske of seizures increases four fold in doses greater than 450 mg per day.
Wellbutrin may be initially administered concurrently with sedatives to minimize agitation.This is not usually required after the first week of therapy.
Insomnia may be decreased by avoiding bedtime doses.
Wellbutrin may be administered with food to lessen gastrointestinal irritation.
Wellbutrin SR and Wellbutrin XL tablets should be swallowed whole; don't break, crush or chew them.
Take Wellbutrin (Bupropion Hydrochloride) exaclty as directed.
Wellbutrin may impair judgment or motor and cognitive skills.Avoid driving and other activities requiring alertness until response to medication is known/
Avoid alcohol during Wellbutrin therapy and consult health care professional before taking other medications with Wellbutrin.
Unused shell of Wellbutrin XL tablets may appear in stool; this is normal.
Women : inform health care professional if pregnancy is planned or suspected.
Notify health care professional of Wellbutrin regimen before treatment or surgery.
You MUST follow-up exams to monitor your progress and you SHOULD participate in pyschotherapy.
Report immediately to your prescriber, mood swings or suicidal thoughts.
Don't chew, crush or divide the tablets.
Wellbutrin tablets may have an odor.
Therapeutic effects may take 2 - 4 weeks; don't increase dose without prescriber's approval.
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